Resume
Professional Experience
2014–present Associate Professor School of Pharmacy, East China University of Science and Technology Shanghai, China 2013–2014 Postdoctoral fellow Advisors: Prof. Xiang-Lei Yang and Prof. Paul Schimmel The Scripps Research Institute La Jolla, California, USA Education 2007–2013 Ph.D., Cellular and Molecular Biology Advisors: Prof. Xiang-Lei Yang and Prof. Paul Schimmel The Scripps Research Institute La Jolla, California, USA 2004–2007 M. Sc., Biochemistry and Molecular Biology Advisor: Prof. Cong-Zhao Zhou School of Life Sciences University of Science and Technology of China Hefei, Anhui, China 1999–2003 B. Sc., Biology Department of Biology Shantou University Shantou, Guangdong, China
 Weiwei He CV 202506.pdf
Research
My research focuses on the study of the modes of action of biologically active natural products. Natural products are considered a unique tool for regulating biological events, due to their structural diversity and biocompatibility. My group works on the identification of the cellular targets of natural products (and synthetic analogues thereof) and elucidation of their modes of action, which are expected to benefit the understanding of the development of diseases such as cancer and the discovery of drug leads. We aim to exploit biologically underappreciated natural products to explore biologically important problems from a non-conventional perspective.
Publications
Yali Wu, Shaonan Wang, Zhicong Guo, Min Sun, Zhen Xu, Yu Du, Fahui Zhu, Yajuan Su, Zhou Xu, Yi Xu, Xu Gong, Ruan Fang, Jiaojiao Hu, Yan Peng, Zhaowen Ding, Cong Liu, Ang Li,* and Weiwei He,* Hapalindole Q suppresses autophagosome−lysosome fusion by promoting YAP1 degradation via chaperone-mediated autophagy. Proc. Natl. Acad. Sci. U. S. A. 2024, 121, e2400809121. Yan Peng, Yumeng Zhang, Ruan Fang, Hao Jiang, Gongcai Lan, Zhou Xu, Yajie Liu, Zhaoyang Nie, Lu Ren, Fengcan Wang, Shou-De Zhang, Yuyong Ma, Peng Yang, Hong-Hua Ge, Wei-Dong Zhang,* Cheng Luo,* Ang Li,* and Weiwei He,* Target identification and mechanistic characterization of indole terpenoid mimics: proper spindle microtubule assembly is essential for Cdh1-mediated proteolysis of CENP-A. Adv. Sci. 2024, 11, 2305593. Shaonan Wang, Min Sun, Yajuan Su, Zhou Xu, Ang Li,* and Weiwei He,* Deucravacitinib induces proteasomal degradation of YAP1 in human glioblastoma cells. Synlett DOI: 10.1055/a-2331-6463. Shaonan Wang, Yali Wu, Mengyu Ba, Zhou Xu, Guoxing Gu, William G. Whittingham, Cong Liu, Ang Li,* and Weiwei He,* Discovery of the lysosome-inhibiting function of acremolactone B. Synlett DOI: 10.1055/a-2325-3938. Weiwei He,# Hongbo Zhang,# Xudong Lin, Lili Zhu, Tingting Zheng, Hao Pei, Yang Tian, Min Zhang, Guoyue Shi, Lei Wu, Jianlong Zhao, Gulinuer Wumaier, Shengqing Li, Yufang Xu, Honglin Li,* and Xuhong Qian* Advancements in life-on-a-chip: The impact of “Beyond Limits Manufacturing” technology. Chin. Chem. Lett. 2024, 35, 109091. Fan Yang, Jie Zhang, Jiacheng Li, Wenbo Ye, Ang Li,* and Weiwei He,* Synthesis of a glucose conjugate of pristimerin and evaluation of its anticancer activity. Chin. Chem. Lett. 2023, 34, 107438. Gongcai Lan, Jie Zhang, Wenbo Ye, Fan Yang, Ang Li,* Weiwei He,* and Wei-Dong Zhang,* Celastrol as a tool for the study of the biological events of metabolic diseases. Sci. China Chem. 2019, 62, 409–416. Jinpeng Pei, Shupeng Zhou, Fan Yang, Yu Sun, Ang Li,* Wei-Dong Zhang,* and Weiwei He* Identification and mechanistic studies of a cell cycle regulator JP18 from a library of synthetic indole terpenoid mimics. Chem. Asian J. 2016, 11, 2715–2718. Zhongyin Zhang, Fan Yang, Jian-Jun Fu, Yun-Heng Shen,* Weiwei He,* and Wei-Dong Zhang,* Delavatine A, a structurally unusual cyclopenta[de] isoquinoline alkaloid from Incarvillea delavayi. RSC Adv. 2016, 6, 65885–65888. Weiwei He,# Ge Bai,# Huihao Zhou, Na Wei, Nicholas M. White, Janelle Lauer, Huaqing Liu, Yi Shi, Calin Dan Dumitru, Karen Lettieri, Veronica Shubayev, Albena Jordanova, Velina Guergueltcheva, Patrick Griffin, Robert W. Burgess, Samuel L. Pfaff,* and Xiang-Lei Yang,* CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase. Nature 2015, 526, 710–714. Weiwei He,# Hui-Min Zhang,# Yeeting E. Chong, Min Guo, Alan G. Marshall, and Xiang-Lei Yang,* Dispersed disease-causing neomorphic mutations on a single protein promote the same localized conformational opening. Proc. Natl. Acad. Sci. U. S. A. 2011, 108, 12307–12312. Weiwei He,# Yi Wang,# Wei Liu, and Cong-Zhao Zhou,* Crystal structure of Saccharomyces cerevisiae 6-phosphogluconate dehydrogenase Gnd1. BMC Struct. Biol. 2007, 7, 38–46.
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